This volume is presented in honour of Heinz Post, who founded a distinc tive and distinguished school of philosophy of science at Chelsea College, University of London. The 'Chelsea tradition' in philosophy of science takes the content of science seriously, as exemplified by the papers presented here. The unifying theme of this work is that of 'Correspondence, Invariance and Heuristics', after the title of a classic and seminal paper by Heinz Post, published in 1971, which is reproduced in this volume (...) with the kind permission of the editors and publishers of Studies in History and Philosophy of Science. Described by Paul Feyerabend in Against Method as "brilliant" and " . . . a partial antidote against the view which I try to defend" (1975, p. 61, fn. 17), this paper, peppered with illustrative examples from the history of science, brings to the fore some of Heinz Post's central concerns: the heuristic criteria used by scientists in constructing their theories, the intertheoretic relationships which these criteria reflect and, in particular, the nature of the correspondence that holds between a theory and its predecessors (and its suc cessors). The appearance of this volume more than twenty years later is an indica tion of the fruitfulness of Post's contribution: philosophers of science continue to explore the issues raised in his 1971 paper. (shrink)

IN Physics VIII, 10, Aristotle seems to commit a serious mistake: just before concluding that the first mover required by all motion everywhere remains invariable and without parts or magnitude, Aristotle apparently locates this mover on the circumference of the cosmos.

The objective of this paper is to outline challenges associated with the inclusion of welfare issues in breeding goals for farm animals and to review the currently available methodologies and discuss their potential advantages and limitations to address these challenges. The methodology for weighing production traits with respect to cost efficiency and market prices are well developed and implemented in animal breeding goals. However, these methods are inadequate in terms of assessing proper values of traits with social and ethical values (...) such as animal welfare, because such values are unlikely to be readily available from the product prices and costs in the market. Defining breeding goals that take animal welfare and ethical concerns into account, therefore, requires new approaches. In this paper we suggest a framework and an approach for defining breeding goals, including animal welfare. The definition of breeding goals including values related to animal welfare requires a multidisciplinary approach with a combination of different methods such as profit equations, stated preference techniques, and selection index theory. In addition, a participatory approach involving different stakeholders such as breeding organizations, food authorities, farmers, and animal welfare organizations should be applied. We conclude that even though these methods provide the necessary tools for considering welfare issues in the breeding goal, the practical application of these methods is yet to be achieved. (shrink)

Translated from the Danish by Walter Lowrie, David Swenson, and Alexander Dru The Danish philosopher Kierkegaard is one of the master thinkers of the modern age, a defining influence on existentialism and on twentieth-century theology, and this brilliantly tailored selection from his vast and varied writings--made by the great English poet W.H Auden--is a perfect introduction to his work. Auden's inspired and incisive response to a thinker who had done much to shape his own beliefs is a fundamental reading of (...) an author whose spirit remains as radical as ever more than 150 years after he wrote. (shrink)

The first translation into English and the first detailed interpretation of Hegel’s System der Sittlichkeit and of Philosophie des Geistes, the two earliest surviving versions of Hegel’s social theory. Hegel’s central concept of the spirit evolved in these two works. An 87-page interpretation by Harris precedes the translations.

BACKGROUND -/- The need for detailed description and modeling of cells drives the continuous generation of large and diverse datasets. Unfortunately, there exists no systematic and comprehensive way to organize these datasets and their information. CELDA (Cell: Expression, Localization, Development, Anatomy) is a novel ontology for the association of primary experimental data and derived knowledge to various types of cells of organisms. -/- RESULTS -/- CELDA is a structure that can help to categorize cell types based on species, anatomical localization, (...) subcellular structures, developmental stages and origin. It targets cells in vitro as well as in vivo. Instead of developing a novel ontology from scratch, we carefully designed CELDA in such a way that existing ontologies were integrated as much as possible, and only minimal extensions were performed to cover those classes and areas not present in any existing model. Currently, ten existing ontologies and models are linked to CELDA through the top-level ontology BioTop. Together with 15.439 newly created classes, CELDA contains more than 196.000 classes and 233.670 relationship axioms. CELDA is primarily used as a representational framework for modeling, analyzing and comparing cells within and across species in CellFinder, a web based data repository on cells (http://cellfinder.org). -/- CONCLUSIONS -/- CELDA can semantically link diverse types of information about cell types. It has been integrated within the research platform CellFinder, where it exemplarily relates cell types from liver and kidney during development on the one hand and anatomical locations in humans on the other, integrating information on all spatial and temporal stages. CELDA is available from the CellFinder website: http://cellfinder.org/about/ontology. (shrink)

Three standard psychometric tests were administered to parents who volunteered their children for a randomised, double-blind placebo-controlled trial of a new asthma drug and to a control group of parents whose children were eligible for the trial but had declined the invitation. The trial took place at a children's hospital in Australia. The subjects comprised 68 parents who had volunteered their children and 42 who had not, a participation rate of 94 per cent and 70 per cent, respectively. The responses (...) of these parents to the Gordon Survey of Interpersonal Values Questionnaire, the Coopersmith Self-Esteem Inventory and the Cattell Sixteen Personality Factor Questionnaire were analysed by computer. There was a marked difference between the psychological profiles of the two groups of parents. Volunteering parents put more value on benevolence while non-volunteering parents were more concerned with power and prestige. The self-esteem of volunteering parents was much lower than that of non-volunteering parents. Finally, volunteering parents were more introverted, exhibited greater anxiety and low supergo, while non-volunteering parents appeared to have greater social confidence and emotional stability. Since an individual's values, self-esteem and personality may be important antecedents of behaviour, these findings suggest that parents who volunteer their children for clinical research are not only socially disadvantaged and emotionally vulnerable, but may also be psychologically predisposed to volunteering. Furthermore, these findings provide evidence for the existence of a psychosocial 'filter' effect of the informed consent procedure, which may be discouraging the better educated, more privileged and psychologically resilient members of society from participation as research subjects. (shrink)